Cadherin 4 antibody (Middle Region)

Catalog No. ABIN2782140

Product Details anti-Cadherin 4 Antibody

Target: Cadherin 4 (CDH4)

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cadherin 4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RIISGDPSGH FSVRTDPVTN EGMVTVVKAV DYELNRAFML TVMVSNQAPL

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 77%

Characteristics: This is a rabbit polyclonal antibody against CDH4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CDH4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 916 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Cadherin 4

Target: Cadherin 4 (CDH4)

Alternative Name: CDH4 (CDH4 Products)

Synonyms: cad4 antibody, rcad antibody, R-cadherin antibody, cadherin-4 antibody, AW120700 antibody, R-Cadh antibody, Rcad antibody, Cdh4l antibody, zgc:136316 antibody, CAD4 antibody, RCAD antibody, cadherin 4 antibody, cadherin 4, type 1, R-cadherin (retinal) antibody, Cadherin-4 antibody, cdh4 antibody, Cdh4 antibody, CDH4 antibody, cdh-4 antibody

Background: CDH4 gene is a classical cadherin from the cadherin superfamily. The protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.
Alias Symbols: CAD4, FLJ22202, FLJ40547, MGC126700, MGC138355, RCAD
Protein Interaction Partner: FUS, Dlg4, CDK5RAP3, CDH2,
Protein Size: 916

Molecular Weight: 82 kDa

Gene ID: 1002

NCBI Accession: NM_001794, NP_001785

UniProt: P55283

Pathways: Cell-Cell Junction Organization, Regulation of Cell Size