SIL1 antibody (N-Term)

Catalog No. ABIN2782036

Product Details anti-SIL1 Antibody

Target: SIL1 (Nucleotide Exchange Factor SIL1 (SIL1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: KETKAEEELD AEVLEVFHPT HEWQALQPGQ AVPAGSHVRL NLQTGEREAK

Predicted Reactivity: Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SIL1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SIL1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 461 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SIL1

Target: SIL1 (Nucleotide Exchange Factor SIL1 (SIL1))

Alternative Name: SIL1 (SIL1 Products)

Synonyms: 1810057E01Rik antibody, AI042831 antibody, wz antibody, BAP antibody, MSS antibody, ULG5 antibody, endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae) antibody, SIL1 nucleotide exchange factor L homeolog antibody, SIL1 nucleotide exchange factor antibody, Sil1 antibody, sil1.L antibody, SIL1 antibody

Background: SIL1 is a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in its gene have been associated with Marinesco-Sjogren syndrome.This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized.
Alias Symbols: BAP, MSS, ULG5
Protein Interaction Partner: UBQLN1, FBXO6, UBC, SMAD9, CCND3, HSPA5,
Protein Size: 461

Molecular Weight: 49 kDa

Gene ID: 64374

NCBI Accession: NM_022464, NP_071909

UniProt: Q9H173

Pathways: Unfolded Protein Response, SARS-CoV-2 Protein Interactome