Ectodysplasin A antibody (Middle Region)

Catalog No. ABIN2781905

Product Details anti-Ectodysplasin A Antibody

Target: Ectodysplasin A (EDA)

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ectodysplasin A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: HLQGQGSAIQ VKNDLSGGVL NDWSRITMNP KVFKLHPRSG ELEVLVDGTY

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against EDA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human EDA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 389 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Ectodysplasin A antibody (ABIN2781905)

Zhao, Watt, Battle, Li, Bondow, Duncan: "Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice." in: Developmental biology, Vol. 317, Issue 2, pp. 614-9, (2008) (PubMed).

Target Details for Ectodysplasin A

Target: Ectodysplasin A (EDA)

Alternative Name: EDA (EDA Products)

Synonyms: ECTD1 antibody, ED1 antibody, ED1-A1 antibody, ED1-A2 antibody, EDA-A1 antibody, EDA-A2 antibody, EDA1 antibody, EDA2 antibody, HED antibody, HED1 antibody, ODT1 antibody, STHAGX1 antibody, XHED antibody, XLHED antibody, si:ch73-223d24.5 antibody, Ed1 antibody, Eda-A1 antibody, Eda-A2 antibody, Ta antibody, tabby antibody, RGD1563178 antibody, ectodysplasin A antibody, ectodysplasin-A antibody, EDA antibody, eda antibody, Eda antibody

Background: EDA is a type II membrane protein that can be cleaved by furin to produce a secreted form. It belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
Alias Symbols: ED1, ED1-A1, ED1-A2, EDA1, EDA2, HED, XHED, XLHED, ODT1, STHAGX1
Protein Interaction Partner: OSTCP1, OSTC, NIPAL3, GIMAP5, SEC22A, LEPROTL1, DOLK, PLN, MAL, EMP3, CYB561, ATP6V0C, EDAR, EDA, EDA2R, FURIN,
Protein Size: 389

Molecular Weight: 41 kDa

Gene ID: 1896

NCBI Accession: NM_001005609, NP_001005609

UniProt: B7ZLU4

Pathways: Tube Formation