LCLAT1 antibody (Middle Region)

Catalog No. ABIN2781857

Product Details anti-LCLAT1 Antibody

Target: LCLAT1 (Lysocardiolipin Acyltransferase 1 (LCLAT1))

Binding Specificity: Middle Region

Reactivity: Mouse, Human, Rat, Rabbit, Horse, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LCLAT1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: YLYSLVKWYF IITIVIFVLQ ERIFGGLEII ELACYRLLHK QPHLNSKKNE

Predicted Reactivity: Cow: 93%, Dog: 92%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against LYCAT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human LYCAT

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 376 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-LCLAT1 antibody (ABIN2781857)

Zou, Synan, Li, Xiong, Manni, Liu, Chen, Zhao, Shiva, Tyurina, Jiang, Lee, Das, Ray, Ray, Kagan, Mallampalli: "LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1." in: Journal of cell science, Vol. 129, Issue 1, pp. 51-64, (2016) (PubMed).

Target Details for LCLAT1

Target: LCLAT1 (Lysocardiolipin Acyltransferase 1 (LCLAT1))

Alternative Name: LYCAT (LCLAT1 Products)

Synonyms: lclat1 antibody, zgc:77380 antibody, wu:fj17g04 antibody, LYCAT antibody, lycat antibody, agpat8 antibody, alcat1 antibody, 1agpat8 antibody, AGPATP8 antibody, 1AGPAT8 antibody, AGPAT8 antibody, ALCAT1 antibody, HSRG1849 antibody, UNQ1849 antibody, AI181996 antibody, Agpat8 antibody, Alcat1 antibody, Gm91 antibody, Lycat antibody, RGD1565906 antibody, lysocardiolipin acyltransferase 1 antibody, lclat1 antibody, LCLAT1 antibody, Lclat1 antibody

Background: LYCAT is an acyl-CoA:lysocardiolipin acyltransferase. It possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. LYCAT recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. LYCAT acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. It converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. LYCAT is required for establishment of the hematopoietic and endothelial lineages.
Alias Symbols: ALCAT1, FLJ37965, UNQ1849, LYCAT, AGPAT8, 1AGPAT8, HSRG1849
Protein Interaction Partner: LNX1, GOPC, RNF2, UBC, ELAVL1,
Protein Size: 376

Molecular Weight: 44 kDa

Gene ID: 253558

NCBI Accession: NM_001002257, NP_001002257

UniProt: Q6UWP7