FGG antibody (Middle Region)

Catalog No. ABIN2781808

Product Details anti-FGG Antibody

Target: FGG (Fibrinogen gamma Chain (FGG))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGG antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: GWTVFQKRLD GSVDFKKNWI QYKEGFGHLS PTGTTEFWLG NEKIHLISTQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 91%

Characteristics: This is a rabbit polyclonal antibody against FGG. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FGG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 437 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FGG

Target: FGG (Fibrinogen gamma Chain (FGG))

Alternative Name: FGG (FGG Products)

Synonyms: FXII antibody, HAF antibody, 3010002H13Rik antibody, AI256424 antibody, fibrinogen antibody, FGG antibody, LOC100220680 antibody, fb60h05 antibody, fb62e01 antibody, wu:fb60h05 antibody, wu:fb62e01 antibody, zgc:56023 antibody, fibrinogen gamma chain antibody, coagulation factor XII (Hageman factor) antibody, fibrinogen gamma chain L homeolog antibody, FGG antibody, F12 antibody, fgg antibody, Fgg antibody, fgg.L antibody, CpipJ_CPIJ006387 antibody, CpipJ_CPIJ010087 antibody

Background: FGG is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in its gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
Alias Symbols: -
Protein Interaction Partner: SUMO2, ASB12, ASB7, ASB6, FN1, VKORC1, KHDRBS2, SERPINA5, VTN, ITGB3, ICAM1, FGG, FGB, FGA, F13B, F13A1, ITGAM,
Protein Size: 437

Molecular Weight: 46 kDa

Gene ID: 2266

NCBI Accession: NM_000509, NP_000500

UniProt: P02679