EXT2 antibody (N-Term)

Catalog No. ABIN2781795

Product Details anti-EXT2 Antibody

Target: EXT2 (Exostosin 2 (EXT2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Zebrafish (Danio rerio), Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXT2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: NELLMAISDS DYYTDDINRA CLFVPSIDVL NQNTLRIKET AQAMAQLSRW

Predicted Reactivity: Cow: 86%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 100%, Rat: 93%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against EXT2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EXT2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 718 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EXT2

Target: EXT2 (Exostosin 2 (EXT2))

Alternative Name: EXT2 (EXT2 Products)

Synonyms: SOTV antibody, AI893565 antibody, EXT2 antibody, ext2 antibody, exostosin glycosyltransferase 2 antibody, exostoses (multiple) 2 antibody, exostoses (multiple) 3 antibody, exostosin glycosyltransferase 2 L homeolog antibody, EXT2 antibody, Ext2 antibody, EXT3 antibody, ext2.L antibody

Background: EXT2 is one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis.This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Alias Symbols: SOTV
Protein Interaction Partner: UBC, GSKIP, SLC22A2, CDKN1A, ANXA7, TK1, SMN1, PFDN1, GALNT5, TRAP1, EXT2, EXT1, CLEC2L, CRB1, HYOU1, STK16, TCEB1, SNCG, RPS29, HNF4A, FABP4, CNTF,
Protein Size: 718

Molecular Weight: 82 kDa

Gene ID: 2132

NCBI Accession: NM_000401, NP_000392

UniProt: Q93063

Pathways: Glycosaminoglycan Metabolic Process