SGCB antibody (Middle Region)

Catalog No. ABIN2781779

Product Details anti-SGCB Antibody

Target: SGCB (Sarcoglycan, beta (43kDa Dystrophin-Associated Glycoprotein) (SGCB))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGCB antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FSTDYETHEF HLPSGVKSLN VQKASTERIT SNATSDLNIK VDGRAIVRGN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SGCB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SGCB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 318 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SGCB

Target: SGCB (Sarcoglycan, beta (43kDa Dystrophin-Associated Glycoprotein) (SGCB))

Alternative Name: SGCB (SGCB Products)

Synonyms: A3b antibody, LGMD2E antibody, SGC antibody, 43kDa antibody, AI747103 antibody, AI844814 antibody, beta-SG antibody, CG5657 antibody, DmSCG-beta antibody, Dmel\\CG5657 antibody, dscgbeta antibody, scg-beta antibody, beta-sarcoglycan antibody, fa03a05 antibody, wu:fa03a05 antibody, zgc:110833 antibody, sarcoglycan beta antibody, sarcoglycan, beta (dystrophin-associated glycoprotein) antibody, Sarcoglycan beta antibody, SarcoGlycaN antibody, uncharacterized LOC5567384 antibody, beta-sarcoglycan antibody, sarcoglycan, beta antibody, sarcoglycan beta L homeolog antibody, SGCB antibody, Sgcb antibody, Scgbeta antibody, sgn-1 antibody, LOC5567384 antibody, CpipJ_CPIJ006944 antibody, sgcb.L antibody, sgcb antibody

Background: SGCB is a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix.The dystrophin-glycoprotein complex (DGC) is a multisubunit protein complex that spans the sarcolemma and provides structural linkage between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. There are 3 main subcomplexes of the DGC: the cytoplasmic proteins dystrophin (DMD, MIM 300377) and syntrophin (SNTA1, MIM 601017), the alpha- and beta-dystroglycans (see MIM 128239), and the sarcoglycans (see, e.g., SGCA, MIM 600119) (Crosbie et al., 2000 [PubMed 10942431]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1235 BC020709.1 1-1235 1236-1833 U31116.1 1257-1854 1834-4229 AK094731.1 47-2442
Alias Symbols: A3b, LGMD2E, SGC
Protein Interaction Partner: UBC, SGCZ, SGCG, SGCD, SGCA,
Protein Size: 318

Molecular Weight: 35 kDa

Gene ID: 6443

NCBI Accession: NM_000232, NP_000223

UniProt: Q16585

Pathways: Myometrial Relaxation and Contraction, Maintenance of Protein Location