PRDM12 antibody (C-Term)

Catalog No. ABIN2781154

Product Details anti-PRDM12 Antibody

Target: PRDM12 (PR Domain Containing 12 (PRDM12))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Zebrafish (Danio rerio), Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRDM12 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NHVRLHTGER PYKCQVCQSA YSQLAGLRAH QKSARHRPPS TALQAHSPAL

Predicted Reactivity: Cow: 93%, Dog: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PRDM12. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PRDM12

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 367 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PRDM12

Target: PRDM12 (PR Domain Containing 12 (PRDM12))

Alternative Name: PRDM12 (PRDM12 Products)

Synonyms: PRDM12 antibody, prdm12 antibody, MGC146714 antibody, PFM9 antibody, pfm9 antibody, Gm998 antibody, PR/SET domain 12 antibody, PR domain containing 12 antibody, PR domain containing 12 L homeolog antibody, PR domain containing 12a antibody, PRDM12 antibody, prdm12 antibody, prdm12.L antibody, Prdm12 antibody, prdm12a antibody

Background: PRDM12 belongs to PR-domain family which are involved in human cancers in an unusual yin-yang fashion. Two products are normally produced from a PR-domain family member which differ by the presence or absence of the PR domain, the PR-plus product is disrupted or underexpressed whereas the PR-minus product is present or overexpressed in cancer cells. This imbalance in the amount of the two products, a result of either genetic or epigenetic events, appears to be an important cause of malignancy. PRDM12 may have a potential role in the pathogenesis of chronic myeloid leukaemia with derivative chromosome 9 deletion.
Alias Symbols: PFM9
Protein Size: 367

Molecular Weight: 40 kDa

Gene ID: 59335

NCBI Accession: NM_021619, NP_067632

UniProt: Q9H4Q4