MNT antibody (N-Term)

Catalog No. ABIN2781100

Product Details anti-MNT Antibody

Target: MNT (MNT, MAX Dimerization Protein (MNT))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Pig, Horse, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MNT antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SIETLLEAAR FLEWQAQQQQ RAREEQERLR LEQEREQEQK KANSLARLAH

Predicted Reactivity: Cow: 93%, Dog: 93%, Horse: 80%, Human: 100%, Mouse: 93%, Pig: 80%, Rabbit: 93%, Rat: 93%, Yeast: 92%

Characteristics: This is a rabbit polyclonal antibody against MNT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MNT

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 582 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MNT

Target: MNT (MNT, MAX Dimerization Protein (MNT))

Alternative Name: MNT (MNT Products)

Synonyms: MAD6 antibody, MXD6 antibody, ROX antibody, bHLHd3 antibody, etID309773.22 antibody, fb16b12 antibody, fb55f03 antibody, wu:fb16b12 antibody, wu:fb55f03 antibody, wu:fd06a08 antibody, wu:fz74f10 antibody, Rox antibody, Mnt antibody, zgc:165490 antibody, mnt antibody, rox antibody, MGC98824 antibody, MAX network transcriptional repressor antibody, max interactor 1, dimerization protein antibody, max binding protein antibody, MAX network transcriptional repressor b antibody, MAX network transcriptional repressor L homeolog antibody, MNT antibody, mxi1 antibody, Mnt antibody, mntb antibody, mnt.L antibody

Background: The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. MNT is a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MAD6, MXD6, ROX, bHLHd3
Protein Interaction Partner: Dlg4, ELAVL1, CEBPA, MAX, MAD1L1, MYC, HDAC1, SIN3A, MNT, MLX, HMGB1,
Protein Size: 582

Molecular Weight: 62 kDa

Gene ID: 4335

NCBI Accession: NM_020310, NP_064706

UniProt: Q99583

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation