POLE4 antibody (N-Term)

Catalog No. ABIN2781088

Product Details anti-POLE4 Antibody

Target: POLE4 (Polymerase (DNA-Directed), epsilon 4 (p12 Subunit) (POLE4))

Binding Specificity: N-Term

Reactivity: Human, Cow, Dog, Horse, Guinea Pig, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLE4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MAAAAAAGSG TPREEEGPAG EAAASQPQAP TSVPGARLSR LPLARVKALV

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against POLE4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human POLE4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 117 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for POLE4

Target: POLE4 (Polymerase (DNA-Directed), epsilon 4 (p12 Subunit) (POLE4))

Alternative Name: POLE4 (POLE4 Products)

Synonyms: 2400007P05Rik antibody, 5830430F06Rik antibody, YHHQ1 antibody, p12 antibody, DNA polymerase epsilon 4, accessory subunit antibody, polymerase (DNA-directed), epsilon 4, accessory subunit antibody, polymerase (DNA-directed), epsilon 4 (p12 subunit) antibody, Pole4 antibody, POLE4 antibody, pole4 antibody

Background: POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.
Alias Symbols: p12, YHHQ1
Protein Interaction Partner: NFYB, gag-pol, NUP133, POLE3, MAP3K7, UBC, YEATS2, POLE4, UBE3A, HSPA13, POLE2, POLE, RAD17,
Protein Size: 117

Molecular Weight: 12 kDa

Gene ID: 56655

NCBI Accession: NM_019896, NP_063949

UniProt: Q9NR33

Pathways: DNA Damage Repair