MESP1 antibody (N-Term)

Catalog No. ABIN2781073

Product Details anti-MESP1 Antibody

Target: MESP1 (Mesoderm Posterior 1 (MESP1))

Binding Specificity: N-Term

Reactivity: Human, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MESP1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SLVSSPDSWG STPADSPVAS PARPGTLRDP RAPSVGRRGA RSSRLGSGQR

Predicted Reactivity: Dog: 85%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against MESP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MESP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 268 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-MESP1 antibody (ABIN2781073)

Tan, Han, Gu, Chen, Wang, Ma, Wu, Feng, Zhang, Wang, Hu, Li, Hao, Zhou: "Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions." in: Journal of tissue engineering and regenerative medicine, (2016) (PubMed).

Hu, Wang, Jiao, Liu, Zhao, Zhou, Zhang, Forde, Wang, Wang, Baylink, Zhang, Gao, Yang, Chen, Ma: "Patient-specific cardiovascular progenitor cells derived from integration-free induced pluripotent stem cells for vascular tissue regeneration." in: Biomaterials, Vol. 73, pp. 51-9, (2015) (PubMed).

Cao, Liang, Huang, Wang, Chen, Chen, Yang: "Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions." in: Cell research, Vol. 23, Issue 9, pp. 1119-32, (2013) (PubMed).

Blin, Nury, Stefanovic, Neri, Guillevic, Brinon, Bellamy, Rücker-Martin, Barbry, Bel, Bruneval, Cowan, Pouly, Mitalipov, Gouadon, Binder, Hagège, Desnos, Renaud, Menasché, Pucéat: "A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates." in: The Journal of clinical investigation, Vol. 120, Issue 4, pp. 1125-39, (2010) (PubMed).

Target Details for MESP1

Target: MESP1 (Mesoderm Posterior 1 (MESP1))

Alternative Name: MESP1 (MESP1 Products)

Synonyms: bHLHc5 antibody, mesp antibody, mesp1 antibody, mespa antibody, CMESO-1 antibody, CMESO2 antibody, MESP1 antibody, mesoderm posterior 1 antibody, mesoderm posterior bHLH transcription factor 1 antibody, mesoderm posterior 1 homolog (mouse) antibody, mesoderm posterior homolog B antibody, mesoderm posterior homolog B L homeolog antibody, Mesp1 antibody, MESP1 antibody, mesp1 antibody, mespb antibody, mespb.L antibody

Background: MESP1 is a transcription factor. MESP1 plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. MESP1 defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways.
Alias Symbols: MGC10676, bHLHc5
Protein Size: 268

Molecular Weight: 28 kDa

Gene ID: 55897

NCBI Accession: NM_018670, NP_061140

UniProt: Q9BRJ9

Pathways: Regulation of Muscle Cell Differentiation