ZNF446 antibody (C-Term)

Catalog No. ABIN2781046

Product Details anti-ZNF446 Antibody

Target: ZNF446 (Zinc Finger Protein 446 (ZNF446))

Binding Specificity: C-Term

Reactivity: Human, Rat, Guinea Pig, Dog, Mouse, Cow, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF446 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SYPCEECGCS FSWKSQLVIH RKSHTGQRRH FCSDCGRAFD WKSQLVIHRK

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 75%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ZNF446. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ZNF446

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 450 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ZNF446

Target: ZNF446 (Zinc Finger Protein 446 (ZNF446))

Alternative Name: ZNF446 (ZNF446 Products)

Background: ZNF446 contains a KRAB and three C(2)H(2) zinc fingers. ZNF446 is a transcription repressor when fused to GAL4 DNA-binding domain and co-transfected with VP-16. Overexpression of ZNF446 in COS-7 cells inhibits the transcriptional activities of SRE and AP-1, suggesting that the ZNF446 protein may act as a transcriptional repressor in mitogen-activated protein kinase (MAPK) signaling pathway to mediate cellular functions.
Alias Symbols: ZSCAN30, ZKSCAN20
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, ZSCAN22, ZNF396, KRT40, ZNF496, PGBD1, LZTS2, ZNF397, ZSCAN16, ZKSCAN7, ZNF446, ZSCAN32, ZNF232, ZSCAN9, ZNF165, ZSCAN21, ZNF24, TRIM27, PIN1, DGCR6, ACTN2, FHL5, DGCR6L, SUFU, ZNF263,
Protein Size: 450

Molecular Weight: 49 kDa

Gene ID: 55663

NCBI Accession: NM_017908, NP_060378

UniProt: Q9NWS9