PRRX2 antibody (N-Term)

Catalog No. ABIN2781006

Product Details anti-PRRX2 Antibody

Target: PRRX2 (Paired Related Homeobox 2 (PRRX2))

Binding Specificity: N-Term

Reactivity: Mouse, Human, Rat, Horse, Pig, Cow, Dog, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRRX2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RKNFSVSHLL DLEEVAAAGR LAARPGARAE AREGAAREPS GGSSGSEAAP

Predicted Reactivity: Cow: 79%, Dog: 79%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Mouse: 79%, Pig: 93%, Rabbit: 79%, Rat: 79%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against PRRX2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PRRX2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 253 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PRRX2 antibody (ABIN2781006)

Tokutomi, Araki, Kataoka, Yamamoto, Kim-Mitsuyama: "Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis." in: Biochemical and biophysical research communications, Vol. 364, Issue 4, pp. 822-30, (2007) (PubMed).

Target Details for PRRX2

Target: PRRX2 (Paired Related Homeobox 2 (PRRX2))

Alternative Name: PRRX2 (PRRX2 Products)

Synonyms: Prx2 antibody, PRRX2 antibody, PMX2 antibody, PRX2 antibody, S8 antibody, (S8) antibody, PRX-2 antibody, paired related homeobox 2 antibody, Prrx2 antibody, PRRX2 antibody

Background: PRRX2 is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.
Alias Symbols: MGC19843, PMX2, PRX2
Protein Interaction Partner: SOX10,
Protein Size: 253

Molecular Weight: 27 kDa

Gene ID: 51450

NCBI Accession: NM_016307, NP_057391

UniProt: Q99811