NFYC antibody (C-Term)

Catalog No. ABIN2780913

Product Details anti-NFYC Antibody

Target: NFYC (Nuclear Transcription Factor Y, gamma (NFYC))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Zebrafish (Danio rerio), Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFYC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: GTQVVQGQIQ TLATNAQQIT QTEVQQGQQQ FSQFTDGQQL YQIQQVTMPA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against NFYC. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NFYC

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 335 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NFYC

Target: NFYC (Nuclear Transcription Factor Y, gamma (NFYC))

Alternative Name: NFYC (NFYC Products)

Synonyms: CBF-C antibody, CBFC antibody, H1TF2A antibody, HAP5 antibody, HSM antibody, NF-YC antibody, fb98f01 antibody, wu:fb98f01 antibody, zgc:55514 antibody, cbf-c antibody, cbfc antibody, h1tf2a antibody, hap5 antibody, hsm antibody, nf-yc antibody, NFYC antibody, Nfyc antibody, nuclear transcription factor Y subunit gamma antibody, nuclear transcription factor Y, gamma antibody, nuclear transcription factor Y subunit gamma L homeolog antibody, nuclear transcription factor-Y gamma antibody, nuclear Y/CCAAT-box binding factor C subunit NF-YC antibody, NFYC antibody, nfyc antibody, nfyc.L antibody, Nfyc antibody

Background: NFYC is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. NFYC forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity.The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence, protein sequence alignments and experiments with mutants. Additional regulation, preliminarily supported by the EST database, may be represented by alternative splicing in this subunit.
Alias Symbols: CBF-C, CBFC, DKFZp667G242, FLJ45775, H1TF2A, HAP5, HSM, NF-YC
Protein Interaction Partner: NFYA, CDK2, UBC, SNX2, NFYB, Cebpb, ELAVL1, GAPDH, KAT2B, TP73, TAF12, TAF11, TAF6, TBPL2, TRIM27, HDAC1, KIAA2018, ARID2, GLTSCR1, GLTSCR1L, ZDHHC17, CIC, POGZ, ATF6, ADNP2, LMO4, SREBF2, SP1, DR1, CSN2, DST, SMAD3, SMAD2, ATF6B, MYC, TBP,
Protein Size: 335

Molecular Weight: 37 kDa

Gene ID: 4802

NCBI Accession: NM_014223, NP_055038

UniProt: Q13952

Pathways: Regulation of Lipid Metabolism by PPARalpha