Retinoid X Receptor gamma antibody (C-Term)

Catalog No. ABIN2780815

Product Details anti-Retinoid X Receptor gamma Antibody

Target: Retinoid X Receptor gamma (RXRG) (Retinoid X Receptor, gamma (RXRG))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoid X Receptor gamma antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LEAYTKQKYP EQPGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against RXRG. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human RXRG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 463 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Retinoid X Receptor gamma antibody (ABIN2780815)

Bungard, McGivan: "Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers." in: Archives of biochemistry and biophysics, Vol. 443, Issue 1-2, pp. 53-9, (2005) (PubMed).

Target Details for Retinoid X Receptor gamma

Target: Retinoid X Receptor gamma (RXRG) (Retinoid X Receptor, gamma (RXRG))

Alternative Name: RXRG (RXRG Products)

Synonyms: NR2B3 antibody, RXRC antibody, zgc:92183 antibody, RXRgamma antibody, RXRG antibody, RXR-gamma antibody, nr2b3 antibody, xrxrg antibody, rxrc antibody, Nr2b3 antibody, NR2B1 antibody, RXR antibody, rxra antibody, rxrg antibody, retinoid X receptor gamma antibody, retinoid X receptor, gamma b antibody, retinoid X receptor gamma L homeolog antibody, retinoid x receptor, gamma a antibody, RXRG antibody, rxrgb antibody, rxrg.L antibody, rxrg antibody, Rxrg antibody, RXRGAMMA antibody, rxrga antibody

Background: RXRG encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. RXRG is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: NR2B3, RXRC
Protein Interaction Partner: NR1H3, NR1H2, RARB, RARA, MPPED2, UBC, CUL1, DCK, NR1H4, NCOR2, NR1I2, VDR, THRB, RARG, PPARD, MAP4, CAMK2B, CEBPZ, HOXD4, AJUBA, RPAP2, LRSAM1, PNO1, CHGB, THRA, NCOA6, PPARG, SRF, CREBBP, PPARA, NR4A1, Nr0b2, ITGB3BP,
Protein Size: 463

Molecular Weight: 51 kDa

Gene ID: 6258

NCBI Accession: NM_006917, NP_008848

UniProt: P48443

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway