HIC1 antibody (Middle Region)

Catalog No. ABIN2780783

Product Details anti-HIC1 Antibody

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Guinea Pig, Dog, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIC1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GETPIAVMGE FANLATSLNP LDPDKDEEEE EEEESEDELP QDISLAAGGE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against HIC1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HIC1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 714 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HIC1 antibody (ABIN2780783)

Stöcklein, Smardova, Macak, Katzenberger, Höller, Wessendorf, Hutter, Dreyling, Haralambieva, Mäder, Müller-Hermelink, Rosenwald, Ott, Kalla: "Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma." in: Oncogene, Vol. 27, Issue 18, pp. 2613-25, (2008) (PubMed).

Target Details for HIC1

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Alternative Name: HIC1 (HIC1 Products)

Synonyms: zfHIC1 antibody, HIC1 antibody, ZBTB29 antibody, ZNF901 antibody, hic-1 antibody, AA408311 antibody, HIC-1 antibody, hypermethylated in cancer 1 antibody, HIC ZBTB transcriptional repressor 1 antibody, hic1 antibody, HIC1 antibody, Hic1 antibody

Background: HIC1 is a transcriptional repressor. HIC1 may act as a tumor suppressor. HIC1 may be involved in development of head, face, limbs and ventral body wall. Defects in HIC1 may be a cause of the facial dysmorphism and additional birth defects (except for lissencephaly) seen in the contiguous gene disorder Miller-Dieker syndrome (MDS), like defective development of the nose, jaws, extremities, gastrointestinal tract, and kidney.
Alias Symbols: ZBTB29, hic-1, ZNF901
Protein Interaction Partner: PIAS4, PIAS3, PIAS2, SP1, STAT3, SIRT1, MTA1, UBE2I, SUMO2, HIC2, TCF4, CTBP2, CTBP1, EED, PHF1, EZH2, PHF19, SUZ12, UBC, MBD3, RBBP4, CHD3, SENP3, HDAC4, PIAS1, ARID1A, HIC1, HDAC1,
Protein Size: 714

Molecular Weight: 74 kDa

Gene ID: 3090

NCBI Accession: NM_006497, NP_006488

UniProt: Q14526

Pathways: Positive Regulation of Response to DNA Damage Stimulus