SIX Homeobox 1 antibody (N-Term)

Catalog No. ABIN2780732

Product Details anti-SIX Homeobox 1 Antibody

Target: SIX Homeobox 1 (SIX1)

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Cow, Sheep, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIX Homeobox 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: ERLGRFLWSL PACDHLHKNE SVLKAKAVVA FHRGNFRELY KILESHQFSP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against Six1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 284 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SIX Homeobox 1

Target: SIX Homeobox 1 (SIX1)

Alternative Name: Six1 (SIX1 Products)

Synonyms: BOS3 antibody, DFNA23 antibody, TIP39 antibody, BB138287 antibody, six1b antibody, six2 antibody, zgc:92332 antibody, XSix1 antibody, six1 antibody, zgc:77345 antibody, SIX homeobox 1 antibody, sine oculis-related homeobox 1 antibody, SIX homeobox 1a antibody, SIX homeobox 1 L homeolog antibody, SIX homeobox 1b antibody, SIX1 antibody, Six1 antibody, six1a antibody, six1.L antibody, six1b antibody

Background: Six1 is a transcription factor that is involved in regulation of organogenesis. It seems to be required for development of kidney, muscle and inner ear and to be involved in later steps of myogenic differentiation. It may be involved in limb tendon and ligament development. It binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter. It is thought to be regulated by association with Dach and Eya proteins. Six1 acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 phosphatase to the SIX1-DACH1 complex. During myogenesis, Six1 seems to act together with EYA2 and DACH2 .
Alias Symbols: BB138287
Protein Interaction Partner: Eya4, Eya1, Smarca4, Neurog1, Neurod1, Smarcc2, Sox2, Smarcc1, Eya3, Dach1,
Protein Size: 284

Molecular Weight: 32 kDa

Gene ID: 20471

NCBI Accession: NM_009189, NP_033215

UniProt: Q62231

Pathways: Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development