MED26 antibody (N-Term)

Catalog No. ABIN2780622

Product Details anti-MED26 Antibody

Target: MED26 (Mediator Complex Subunit 26 (MED26))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Cow, Dog, Rabbit, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MED26 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TAAPASPQQI RDRLLQAIDP QSNIRNMVAV LEVISSLEKY PITKEALEET

Predicted Reactivity: Cow: 93%, Dog: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against MED26. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MED26

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 600 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MED26

Target: MED26 (Mediator Complex Subunit 26 (MED26))

Alternative Name: MED26 (MED26 Products)

Background: MED26 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-261 AC024075.4 20290-20550 c 262-726 AF104253.1 1-465 727-3184 AK128435.1 1414-3871
Alias Symbols: CRSP7, CRSP70
Protein Interaction Partner: MED19, MED13, MED12, MED21, MED11, TAF8, MED8, MED30, EAF1, MED10, TAF3, MED25, MED28, ICE2, EAF2, MED29, MED9, MED18, MED15, MED31, MED4, AFF4, MED13L, ICE1, CDK19, ELL2, MED16, MED6, MED20, MED7, MED27, MED17, MED23, MED14, ELL, TAF15, TCEB3, TCEA1, TBP
Protein Size: 600

Molecular Weight: 65 kDa

Gene ID: 9441

NCBI Accession: NM_004831, NP_004822

UniProt: O95402

Pathways: Regulation of Lipid Metabolism by PPARalpha