AF9 antibody (N-Term)

Catalog No. ABIN2780604

Product Details anti-AF9 Antibody

Target: AF9 (MLLT3) (Protein AF-9 (MLLT3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Cow, Rat, Dog, Rabbit, Horse, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AF9 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 86%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against MLLT3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MLLT3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 568 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AF9

Target: AF9 (MLLT3) (Protein AF-9 (MLLT3))

Alternative Name: MLLT3 (MLLT3 Products)

Synonyms: fc39c11 antibody, wu:fc39c11 antibody, zgc:110210 antibody, AF9 antibody, YEATS3 antibody, 2210011H10Rik antibody, 2610012I03Rik antibody, 3830408D16Rik antibody, Af9 antibody, D4Ertd321e antibody, Af-9 antibody, MLLT3, super elongation complex subunit antibody, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 antibody, mllt3 antibody, MLLT3 antibody, Mllt3 antibody

Background: MLLT3 is a regulator of early erythroid and megakaryocytic cell fate in the human system. Expression of MLLT3 in human CD34+ cells induces acute myeloid, lymphoid, or mixed-lineage leukemia in immunodeficient mice. Translocation t (9,11)(p22,q23), a chromosomal aberration involving MLLT3 is associated with acute leukemias.
Alias Symbols: AF9, FLJ2035, YEATS3
Protein Interaction Partner: CDK9, HSP90B1, EAF1, AFF4, ELL2, MED26, ELL, MLLT3, AFF1, MLLT1, CDK6, CCNT1, CCNT2, APP, Cbx8, DOT1L, PAF1, KMT2A, BCOR, MLLT10, RNF2, AFF3, EEF2, ACACA, PCGF1, ELL3, NIPBL, SIRT1, LRIF1, RBM48, APPBP2, MCM6, PTN, EEF1A1, SGK1,
Protein Size: 568

Molecular Weight: 63 kDa

Gene ID: 4300

NCBI Accession: NM_004529, NP_004520

UniProt: P42568