ETV5 antibody (N-Term)

Catalog No. ABIN2780594

Product Details anti-ETV5 Antibody

Target: ETV5 (Ets Variant 5 (ETV5))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ETV5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PFMVPGKSRS EECRGRPVID RKRKFLDTDL AHDSEELFQD LSQLQEAWLA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against ETV5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ETV5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 510 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ETV5

Target: ETV5 (Ets Variant 5 (ETV5))

Alternative Name: ETV5 (ETV5 Products)

Synonyms: ERM antibody, etv5 antibody, fj87h10 antibody, id:ibd5133 antibody, wu:fj87h10 antibody, zgc:55647 antibody, 1110005E01Rik antibody, 8430401F14Rik antibody, ETS variant 5 antibody, ets variant 5 antibody, ets variant 5a antibody, ETV5 antibody, Etv5 antibody, etv5a antibody

Background: ETV5 Contains 1 ETS DNA-binding domain and belongs to the ETS family. The ETV5 gene expression is regulated by the conventional PKC (cPKC) pathway.ETV5 is subject to SUMO modification and this post-translational modification causes inhibition of transcription-enhancing activity Phosphorylated ETV5 and the actin cytoskeleton regulate CD44-mediated hyaluronan binding in myeloid cells. ERMs (ezrin/radixin/moesin) function as adaptor molecules in the interactions of adhesion receptors and intracellular tyrosine kinases. ETV5 can cooperate with c-Jun and has a role in progression of breast cancer.
Alias Symbols: ERM
Protein Interaction Partner: RFWD2, HDAC11, DHRS7, SEZ6L2, SLC22A2, HOXD9, CYP3A5, CCR5, CISH, AMH, APP, BRCA1, ELAVL1, SUMO2, UBC, AR,
Protein Size: 510

Molecular Weight: 58 kDa

Gene ID: 2119

NCBI Accession: NM_004454, NP_004445

UniProt: P41161

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development