ZNF259 antibody (C-Term)

Catalog No. ABIN2780558

Product Details anti-ZNF259 Antibody

Target: ZNF259 (znf259) (Zinc Finger Protein 259 (znf259))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Zebrafish (Danio rerio), Guinea Pig, Horse, Goat, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF259 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: GNSYLQNVYA PEDDPEMKVE RYKRTFDQNE ELGLNDMKTE GYEAGLAPQR

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 85%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against ZNF259. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ZNF259

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 459 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ZNF259

Target: ZNF259 (znf259) (Zinc Finger Protein 259 (znf259))

Alternative Name: ZNF259 (znf259 Products)

Synonyms: RGD1562173 antibody, zpr1 antibody, ZNF259 antibody, ZPR1 antibody, Zfp259 antibody, fc17g10 antibody, si:rp71-56i13.4 antibody, wu:fc17g10 antibody, zgc:56478 antibody, AI303781 antibody, Znf259 antibody, ZPR1 zinc finger antibody, ZPR1 zinc finger L homeolog antibody, Zpr1 antibody, ZPR1 antibody, zpr1 antibody, zpr1.L antibody

Background: ZNF259 may be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus. ZNF259 binds to the EGFR and is released from the receptor after activation.ZNF259 is essential for cell viability and its interaction with eEF-1alpha contributes to normal cellular proliferation.ZNF259 translocates from the cytoplasm to the nucleus after treatment of cells with mitogens. ZNF259 accumulates in the nucleolus of proliferating cells. Loss of ZNF259 caused disruption of nucleolar function, including preribosomal RNA expression. ZNF259 is an essential protein that is required for normal nucleolar function in proliferating cells.
Alias Symbols: ZPR1
Protein Interaction Partner: UBC, P3H1, FKBP10, RPRD1B, OSGEP, PPME1, SZRD1, ARIH1, HSPBP1, ACTR2, ACTR3, ARPC4, UBA2, TOM1L1, OGT, SURF2, PPP1R7, LPP, HSF1, AGFG1, HNRNPF, BAG1, ALAD, MPP3, SRXN1, NUDCD2, UBL7, THOC7, KLC2, UBQLN4, UFM1, UFC1, UBXN1, UHRF1, PHPT1, TES, UBXN7, HYPK,
Protein Size: 459

Molecular Weight: 51 kDa

Gene ID: 8882

NCBI Accession: NM_003904, NP_003895

UniProt: O75312