Spt6 antibody (N-Term)

Catalog No. ABIN2780483

Product Details anti-Spt6 Antibody

Target: Spt6 (SUPT6H) (Suppressor of Ty 6 Homolog (SUPT6H))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio), Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Spt6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: EAEESEEEYN DEGEVVPRVT KKFVEEEDDD EEEEEENLDD QDEQGNLKGF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Yeast: 77%, Zebrafish: 77%

Characteristics: This is a rabbit polyclonal antibody against SUPT6H. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SUPT6H

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1726 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Spt6

Target: Spt6 (SUPT6H) (Suppressor of Ty 6 Homolog (SUPT6H))

Alternative Name: SUPT6H (SUPT6H Products)

Synonyms: SPT6 antibody, SPT6H antibody, emb-5 antibody, 5131400N11Rik antibody, AI132449 antibody, Supt6h antibody, mKIAA0162 antibody, Spt6 antibody, wu:fj42h11 antibody, SUPT6H antibody, spt6 antibody, spt6h antibody, MGC146884 antibody, SPT6 homolog, histone chaperone antibody, suppressor of Ty 6 antibody, SUPT6H,-like protein to suppressor of ty 6 antibody, transcription elongation factor SPT6 antibody, suppressor of Ty 6 homolog (S. cerevisiae) antibody, chromatin-remodeling histone chaperone antibody, SUPT6H antibody, Supt6 antibody, Supt6h antibody, supt6h antibody, LOC100092175 antibody, SPT6 antibody

Background: SUPT6H may be functionally analogous to SPT6 and emb-5 and may therefore regulate transcription through establishment or maintenance of chromatin structure. Spt6 may also participates in the regulation of transcription by RNA polymerase II (RNAPII). Human Spt6 (hSpt6) is a classic transcription elongation factor that enhances the rate of RNAPII elongation. HSpt6 is capable of stimulating transcription elongation both individually and in concert with DRB sensitivity-inducing factor (DSIF).
Alias Symbols: SPT6, SPT6H, emb-5
Protein Interaction Partner: CEP76, HAUS2, CEP250, TUBGCP3, CEP57, VCP, TUBG1, TP53, EMD, CDKN1A, UBC, EED, BMI1, POLR2C, ERBB2, CSNK2A1, BRCA1, MDC1, PAAF1, SIRT7, SUMO2, POLR2A, IWS1, WDR48, TCEA1,
Protein Size: 1726

Molecular Weight: 199 kDa

Gene ID: 6830

NCBI Accession: NM_003170, NP_003161

UniProt: Q7KZ85

Pathways: Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Production of Molecular Mediator of Immune Response