PBX2 antibody (C-Term)

Catalog No. ABIN2780441

Product Details anti-PBX2 Antibody

Target: PBX2 (Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Dog, Horse, Cow, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PBX2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PGGYGDNLGG GQMYSPREMR ANGSWQEAVT PSSVTSPTEG PGSVHSDTSN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PBX2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PBX2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 430 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PBX2

Target: PBX2 (Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2))

Alternative Name: PBX2 (PBX2 Products)

Synonyms: G17 antibody, HOX12 antibody, PBX2MHC antibody, AU043397 antibody, pbxy antibody, wu:fb73g03 antibody, hox12 antibody, pbx2mhc antibody, PBX2P1 antibody, PBX homeobox 2 antibody, pre B cell leukemia homeobox 2 antibody, pre-B-cell leukemia homeobox 2 antibody, pre-B-cell leukemia homeobox 2 L homeolog antibody, PBX2 antibody, Pbx2 antibody, pbx2 antibody, pbx2.L antibody

Background: PBX2 is a ubiquitously expressed member of the TALE/PBX homeobox family. PBX2 gene was identified by its similarity to a homeobox gene which is involved in t(1,19) translocation in acute pre-B-cell leukemias. PBX2 is a transcriptional activator which binds to the TLX1 promoter. This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1,19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.
Alias Symbols: G17, HOX12, PBX2MHC
Protein Interaction Partner: CARD9, HOXA1, SOX2, ELAVL1, COPS6, ZDHHC7, SKIV2L2, SMYD3, MCRS1, CCDC88B, RPS6KC1, PBX2, PBX1, CENPBD1, DCTN3, NUP62, BAIAP2, IKBKAP, UBE2E1, PKNOX1, BLOC1S1, RPL4, HOXB8, HOXA9,
Protein Size: 430

Molecular Weight: 46 kDa

Gene ID: 5089

NCBI Accession: NM_002586, NP_002577

UniProt: P40425

Pathways: Skeletal Muscle Fiber Development