MAZ antibody (N-Term)

Catalog No. ABIN2780422

Product Details anti-MAZ Antibody

Target: MAZ (MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAZ antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: FPVFPCTLLA PPFPVLGLDS RGVGGLMNSF PPPQGHAQNP LQVGAELQSR

Predicted Reactivity: Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MAZ. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MAZ

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 477 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-MAZ antibody (ABIN2780422)

Smits, Wurdinger, van het Hof, Drexhage, Geerts, Wesseling, Noske, Vandertop, de Vries, Reijerkerk: "Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, Issue 6, pp. 2639-47, (2012) (PubMed).

Target Details for MAZ

Target: MAZ (MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ))

Alternative Name: MAZ (MAZ Products)

Synonyms: PUR1 antibody, Pur-1 antibody, SAF-1 antibody, SAF-2 antibody, SAF-3 antibody, ZF87 antibody, ZNF801 antibody, Zif87 antibody, MYC associated zinc finger protein antibody, MYC-associated zinc finger protein (purine-binding transcription factor) antibody, myc-associated zinc finger protein (purine-binding transcription factor) L homeolog antibody, MAZ antibody, Maz antibody, maz.L antibody

Background: MAZ may function as a transcription factor with dual roles in transcription initiation and termination.It binds to two sites, ME1a1 and ME1a2, within the c-myc promoter having greater affinity for the former. It also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors.
Alias Symbols: PUR1, Pur-1, SAF-1, SAF-2, ZF87, ZNF801, Zif87, SAF-3
Protein Interaction Partner: HECW2, MAPK14, BPTF, JUN, FOS, KEAP1, DCC, CSNK2A1,
Protein Size: 477

Molecular Weight: 48 kDa

Gene ID: 4150

NCBI Accession: NM_002383, NP_002374

UniProt: P56270

Pathways: Chromatin Binding