FLI1 antibody (N-Term)

Catalog No. ABIN183608

Product Details anti-FLI1 Antibody

Target: FLI1 (Friend Leukemia Virus Integration 1 (FLI1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FLI1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against FLI1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FLI1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 452 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FLI1 antibody (ABIN183608)

Bujor, Haines, Padilla, Christmann, Junie, Sampaio-Barros, Lafyatis, Trojanowska: "Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1." in: International journal of molecular medicine, Vol. 30, Issue 6, pp. 1473-80, (2012) (PubMed).

Target Details for FLI1

Target: FLI1 (Friend Leukemia Virus Integration 1 (FLI1))

Alternative Name: FLI1 (FLI1 Products)

Synonyms: EWSR2 antibody, SIC-1 antibody, FLI1 antibody, fli antibody, Xfli antibody, fli1 antibody, Xfli1 antibody, fli-1 antibody, Xfli-1 antibody, MGC121593 antibody, Fli-1 antibody, Sic1 antibody, cb855 antibody, wu:fc45b11 antibody, xlfli antibody, Fli-1 proto-oncogene, ETS transcription factor antibody, Fli-1 proto-oncogene, ETS transcription factor S homeolog antibody, Friend leukemia integration 1 antibody, Fli-1 proto-oncogene, ETS transcription factor a antibody, Fli-1 proto-oncogene, ETS transcription factor L homeolog antibody, FLI1 antibody, Fli1 antibody, fli1.S antibody, fli1 antibody, fli1a antibody, fli1.L antibody

Background: Friend leukemia integration 1 (Fli-1) is a member of the ETS family of transcriptional regulatory proteins that contain a highly conserved and structurally unique DNA binding ETS domain.
Alias Symbols: EWSR2, SIC-1
Protein Interaction Partner: SOX30, SIAH1, CTBP2, UBC, SMAD9, GATA1, FMNL1, SUMO1, UBE2I, PIAS2, PIAS1, SMAD3, ETV6, KLF1, TDP2, SRF, ERG, EWSR1, ELK1, BRCA1, TGFBR2, STYXL1,
Protein Size: 452

Molecular Weight: 51 kDa

Gene ID: 2313

NCBI Accession: NM_002017, NP_002008

UniProt: Q01543