ATF4 antibody (N-Term)

Catalog No. ABIN2780377

Product Details anti-ATF4 Antibody

Target: ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATF4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VLAGDLMSPF DQSGLGAEES LGLLDDYLEV AKHLKPHGFS SDKAGSSEWP

Predicted Reactivity: Cow: 86%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 92%, Rat: 100%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against Atf4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 349 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ATF4 antibody (ABIN2780377)

Kalinec, Thein, Parsa, Yorgason, Luxford, Urrutia, Kalinec: "Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways." in: Hearing research, Vol. 313, pp. 26-37, (2014) (PubMed).

Target Details for ATF4

Target: ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))

Alternative Name: Atf4 (ATF4 Products)

Background: The function of Atf4 remains unknown.
Alias Symbols: Atf-4, C/ATF, CREB2, MGC96460, TAXREB67
Protein Interaction Partner: Egln3, Ubc, Hif1a, Satb2, Fam175b, Trib3, Gabbr2, Gabbr1, Jun, Fos, Dapk3, Rps6ka3, Tnfsf11, Prkaca,
Protein Size: 349

Molecular Weight: 38 kDa

Gene ID: 11911

NCBI Accession: NM_009716, NP_033846

UniProt: Q5U4B2

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response