PPARD antibody (N-Term)

Catalog No. ABIN2780303

Product Details anti-PPARD Antibody

Target: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPARD antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FGRMPEAEKR KLVAGLTASE GCQHNPQLAD LKAFSKHIYN AYLKNFNMTK

Predicted Reactivity: Cow: 85%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 93%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PPARD. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of mouse PPARD

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 440 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PPARD antibody (ABIN2780303)

Kramerova, Ermolova, Eskin, Hevener, Quehenberger, Armando, Haller, Romain, Nelson, Spencer: "Failure to up-regulate transcription of genes necessary for muscle adaptation underlies limb girdle muscular dystrophy 2A (calpainopathy)." in: Human molecular genetics, Vol. 25, Issue 11, pp. 2194-2207, (2016) (PubMed).

Ares-Carrasco, Picatoste, Camafeita, Carrasco-Navarro, Zubiri, Ortiz, Egido, López, Tuñón, Lorenzo: "Proteome changes in the myocardium of experimental chronic diabetes and hypertension: role of PPAR? in the associated hypertrophy." in: Journal of proteomics, Vol. 75, Issue 6, pp. 1816-29, (2012) (PubMed).

Yang, Zhang, Zhou, Yan, Adell, Sun: "Biological function and prognostic significance of peroxisome proliferator-activated receptor ? in rectal cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 11, pp. 3760-70, (2011) (PubMed).

Yang, Olsson, Pfeifer, Jönsson, Zhou, Jiang, Fredriksson, Zhang, Sun: "Knockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell-fibronectin adhesion of colon cancer cells." in: Oncogene, Vol. 29, Issue 4, pp. 516-26, (2010) (PubMed).

Target Details for PPARD

Target: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Alternative Name: PPARD (PPARD Products)

Synonyms: FAAR antibody, NR1C2 antibody, NUC1 antibody, NUCI antibody, NUCII antibody, PPARB antibody, NUC-1 antibody, Nr1c2 antibody, PPAR-beta antibody, PPAR-delta antibody, PPAR[b] antibody, PPARdelta antibody, Pparb antibody, Pparb/d antibody, PPARBETA antibody, ppard antibody, pparb antibody, PPARD antibody, PPAR-D/B antibody, peroxisome proliferator activated receptor delta antibody, peroxisome proliferator activator receptor delta antibody, peroxisome proliferator activated receptor delta S homeolog antibody, peroxisome proliferator-activated receptor delta antibody, PPARD antibody, Ppard antibody, ppard.S antibody, ppard antibody

Background: PPARdelta is pivotal to control the program for fatty acid oxidation in the skeletal muscle, thereby ameliorating obesity and insulin resistance through its activation in obese animals.
Alias Symbols: NUC1, NUC-1, Nr1c2, Pparb, PPAR[b], Pparb/d, PPAR-beta, PPARdelta, PPAR-delta
Protein Interaction Partner: Scand1, HDAC7, NCOR2, BCL6, HSP90AA1, Apc, Rxrg, Rxra, Dut, GADD45A,
Protein Size: 440

Molecular Weight: 48 kDa

Gene ID: 19015

NCBI Accession: NM_011145, NP_035275

UniProt: P35396

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Monocarboxylic Acid Catabolic Process, Smooth Muscle Cell Migration, Positive Regulation of fat Cell Differentiation