SSX2 antibody (C-Term)

Catalog No. ABIN2780224

Product Details anti-SSX2 Antibody

Target: SSX2 (Synovial Sarcoma, X Breakpoint 2 (SSX2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSX2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: HRWSSQNTHN IGRFSLSTSM GAVHGTPKTI THNRDPKGGN MPGPTDCVRE

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against SSX2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SSX2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 223 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SSX2 antibody (ABIN2780224)

Jung, Fischer, Imig, Kleber, Nuber, Reinshagen, Kamradt, Grobholz, Knuth, Renner, Wadle: "Yeast-based identification of prostate tumor antigens provides an effective vaccine platform." in: Anticancer research, Vol. 30, Issue 3, pp. 895-902, (2010) (PubMed).

Target Details for SSX2

Target: SSX2 (Synovial Sarcoma, X Breakpoint 2 (SSX2))

Alternative Name: SSX2 (SSX2 Products)

Synonyms: CT5.2 antibody, CT5.2A antibody, HD21 antibody, HOM-MEL-40 antibody, SSX antibody, SSX2 antibody, SSX3 antibody, SSX family member 2 antibody, protein SSX2 antibody, synovial sarcoma, X breakpoint 2 antibody, SSX2 antibody, LOC741661 antibody, Ssx2 antibody

Background: SSX2 belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X,18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X,18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
Alias Symbols: HD21, HOM-MEL-40, MGC119055, MGC15364, MGC3884, SSX, SSX2B, CT5.2a
Protein Interaction Partner: KRT40, SSX2IP, RAB3IP, SYCE1, ZMIZ2, MAGEC2, AKAP9, ZBED1, TAX1BP1, BLZF1, SUZ12, EED, SMARCA5, TLE1, SMARCA2, HDAC2, HDAC1, EZH2, ATF2, RNF2,
Protein Size: 223

Molecular Weight: 25 kDa

Gene ID: 6757

NCBI Accession: NM_003147, NP_003138