FXYD5 antibody (N-Term)

Catalog No. ABIN2780210

Product Details anti-FXYD5 Antibody

Target: FXYD5 (FXYD Domain Containing Ion Transport Regulator 5 (FXYD5))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FXYD5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LQPTSPTPTW PADETPQPQT QTQQLEGTDG PLVTDPETHK STKAAHPTDD

Predicted Reactivity: Human: 100%, Mouse: 100%, Yeast: 90%

Characteristics: This is a rabbit polyclonal antibody against FXYD5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FXYD5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 178 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FXYD5 antibody (ABIN2780210)

Song, Li, Sun, Zhao: "Fxyd5 activates the NF‑κB pathway and is involved in chondrocytes inflammation and extracellular matrix degradation." in: Molecular medicine reports, Vol. 25, Issue 4, (2022) (PubMed).

Target Details for FXYD5

Target: FXYD5 (FXYD Domain Containing Ion Transport Regulator 5 (FXYD5))

Alternative Name: FXYD5 (FXYD5 Products)

Synonyms: FXYD5 antibody, DYSAD antibody, IWU1 antibody, KCT1 antibody, OIT2 antibody, PRO6241 antibody, RIC antibody, EF-8 antibody, Oit2 antibody, FXYD domain containing ion transport regulator 5 antibody, FXYD domain-containing ion transport regulator 5 antibody, FXYD5 antibody, Fxyd5 antibody

Background: FXYD5 is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIon Channel (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIon Channel) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, has not been characterized as a protein.
Alias Symbols: RIC, IWU1, KCT1, OIT2, DYSAD, HSPC113, PRO6241
Protein Interaction Partner: UBC,
Protein Size: 178

Molecular Weight: 20 kDa

Gene ID: 53827

NCBI Accession: NM_144779, NP_659003

UniProt: Q96DB9