NMRAL1 antibody (N-Term)
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- Target See all NMRAL1 Antibodies
- NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))
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Binding Specificity
- N-Term
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Reactivity
- Rat, Mouse, Cow, Dog, Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NMRAL1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- GATGAQGGSV ARALLEDGTF RIRVVTRNPE QRAAKELKQQ GAEVVRGDQD
- Predicted Reactivity
- Cow: 79%, Dog: 79%, Mouse: 100%, Pig: 86%, Rat: 86%
- Characteristics
- This is a rabbit polyclonal antibody against Nmral1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the n terminal region of mouse Nmral1
- Top Product
- Discover our top product NMRAL1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 309 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))
- Alternative Name
- Nmral1 (NMRAL1 Products)
- Synonyms
- HSCARG antibody, SDR48A1 antibody, 1110025F24Rik antibody, AI256624 antibody, RGD1311451 antibody, NmrA like redox sensor 1 antibody, NmrA-like family domain containing 1 antibody, NMRAL1 antibody, Nmral1 antibody
- Background
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Nmral1 is a redox sensor protein. Nmral1 undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP+ levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH.Nmral1 has higher affinity for NADPH than for NADP+. Binding to NADPH is necessary to form a stable dimer.
Alias Symbols: 1110025F24Rik, AI256624
Protein Size: 309 - Molecular Weight
- 34 kDa
- Gene ID
- 67824
- NCBI Accession
- NM_026393, NP_080669
- UniProt
- Q8K2T1
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