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NMRAL1 antibody (N-Term)

NMRAL1 Reactivity: Rat, Mouse, Cow, Dog, Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2780056
  • Target See all NMRAL1 Antibodies
    NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))
    Binding Specificity
    • 8
    • 1
    • 1
    N-Term
    Reactivity
    • 12
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat, Mouse, Cow, Dog, Pig
    Host
    • 10
    • 2
    Rabbit
    Clonality
    • 12
    Polyclonal
    Conjugate
    • 8
    • 2
    • 1
    • 1
    This NMRAL1 antibody is un-conjugated
    Application
    • 7
    • 7
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    GATGAQGGSV ARALLEDGTF RIRVVTRNPE QRAAKELKQQ GAEVVRGDQD
    Predicted Reactivity
    Cow: 79%, Dog: 79%, Mouse: 100%, Pig: 86%, Rat: 86%
    Characteristics
    This is a rabbit polyclonal antibody against Nmral1. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the n terminal region of mouse Nmral1
    Top Product
    Discover our top product NMRAL1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 309 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))
    Alternative Name
    Nmral1 (NMRAL1 Products)
    Synonyms
    HSCARG antibody, SDR48A1 antibody, 1110025F24Rik antibody, AI256624 antibody, RGD1311451 antibody, NmrA like redox sensor 1 antibody, NmrA-like family domain containing 1 antibody, NMRAL1 antibody, Nmral1 antibody
    Background
    Nmral1 is a redox sensor protein. Nmral1 undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP+ levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH.Nmral1 has higher affinity for NADPH than for NADP+. Binding to NADPH is necessary to form a stable dimer.
    Alias Symbols: 1110025F24Rik, AI256624
    Protein Size: 309
    Molecular Weight
    34 kDa
    Gene ID
    67824
    NCBI Accession
    NM_026393, NP_080669
    UniProt
    Q8K2T1
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