FOXA3 antibody (C-Term)

Catalog No. ABIN2779850

Product Details anti-FOXA3 Antibody

Target: FOXA3 (Forkhead Box A3 (FOXA3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXA3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: YNFNHPFSIN NLMSEQTSTP SKLDVGFGGY GAESGEPGVY YQSLYSRSLL

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 79%, Horse: 86%, Human: 86%, Mouse: 100%, Pig: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Foxa3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the c terminal region of mouse Foxa3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 353 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FOXA3

Target: FOXA3 (Forkhead Box A3 (FOXA3))

Alternative Name: Foxa3 (FOXA3 Products)

Synonyms: FOXA3 antibody, Zffkh1 antibody, fa11c04 antibody, fkd2 antibody, forkhead-2 antibody, wu:fa11c04 antibody, wu:fc37a08 antibody, zf-FKH1 antibody, FKHH3 antibody, HNF3G antibody, TCF3G antibody, HNF3-G antibody, Hnf-3g antibody, Hnf3g antibody, Tcf-3g antibody, Tcf3g antibody, forkhead box A3 antibody, FOXA3 antibody, foxa3 antibody, Foxa3 antibody

Background: Foxa3 is a transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Foxa3 is originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Foxa3 interacts with the cis-acting regulatory regions of these genes.Foxa3 is involved in glucose homeostasis, activates GLUT2 transcription and regulation of neuronal-specific transcription. Foxa3 is also involved in regulation of spermatogenesis, required for the maintenance of the testicular germ cell population and male fertility.
Alias Symbols: Hnf-3g, Hnf3g, Tcf-3g, Tcf3g
Protein Size: 353

Molecular Weight: 37 kDa

Gene ID: 15377

NCBI Accession: NM_008260, NP_032286

UniProt: P35584

Pathways: Carbohydrate Homeostasis