Arx antibody (Middle Region)

Catalog No. ABIN2779819

Product Details anti-Arx Antibody

Target: Arx (ARX) (Aristaless Related Homeobox (ARX))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Arx antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TGAEDDEEEL LEDEEDEEEE EELLEDDDEE LLEDDARALL KEPRRCSVAT

Predicted Reactivity: Dog: 93%, Guinea Pig: 93%, Horse: 79%, Human: 93%, Mouse: 100%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ARX. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse ARX

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 564 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Arx antibody (ABIN2779819)

Price, Yoo, Burgess, Deng, Hrachovy, Frost, Noebels et al.: "A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral ..." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 27, pp. 8752-63, (2009) (PubMed).

Condomines, Hose, Rème, Requirand, Hundemer, Schoenhals, Goldschmidt, Klein: "Gene expression profiling and real-time PCR analyses identify novel potential cancer-testis antigens in multiple myeloma." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 2, pp. 832-40, (2009) (PubMed).

Target Details for Arx

Target: Arx (ARX) (Aristaless Related Homeobox (ARX))

Alternative Name: ARX (ARX Products)

Synonyms: CT121 antibody, EIEE1 antibody, ISSX antibody, MRX29 antibody, MRX32 antibody, MRX33 antibody, MRX36 antibody, MRX38 antibody, MRX43 antibody, MRX54 antibody, MRX76 antibody, MRX87 antibody, MRXS1 antibody, PRTS antibody, phox2a antibody, RGD1562672 antibody, arx antibody, arx-a antibody, arx-b antibody, arx2 antibody, ct121 antibody, issx antibody, mrx29 antibody, mrx32 antibody, mrx33 antibody, mrx36 antibody, mrx38 antibody, mrx43 antibody, mrx54 antibody, mrx76 antibody, mrx87 antibody, mrxs1 antibody, prt5 antibody, xARX antibody, aristaless related homeobox antibody, aristaless related homeobox a antibody, aristaless related homeobox L homeolog antibody, Arx antibody, ARX antibody, arxa antibody, arx.L antibody

Background: ARX (Aristaless-related genes), a subset of the Paired-related homeobox genes, is a group of regulators of essential events during vertebrate embryogenesis. Arx was highly conserved between mouse and zebrafish. Studies have disclosed its neuromeric expression in the forebrain and longitudinal expression in the floor plate in mouse and zebrafish. It is also expressed in the dorsal telencephalon (presumptive cerebral cortex) of mouse embryos.
Protein Size: 564

Molecular Weight: 58 kDa

Gene ID: 11878

NCBI Accession: NM_007492, NP_031518

UniProt: O35085