NOTO antibody (N-Term)

Catalog No. ABIN2779813

Product Details anti-NOTO Antibody

Target: NOTO (Notochord Homeobox (NOTO))

Binding Specificity: N-Term

Reactivity: Mouse, Human, Cow, Rat, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOTO antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VQPGSLRPCP GAVSPVVPRR LARGRLESSF SVEAILARPK TRELAATSLP

Predicted Reactivity: Cow: 86%, Dog: 85%, Guinea Pig: 93%, Human: 93%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Noto. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the n terminal region of mouse Noto

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 240 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NOTO

Target: NOTO (Notochord Homeobox (NOTO))

Alternative Name: Noto (NOTO Products)

Synonyms: Xnot-2 antibody, Xnot2 antibody, not antibody, nota antibody, noto antibody, RGD1562910 antibody, Xnot antibody, Flh antibody, MmNot antibody, Not antibody, tc antibody, Znot antibody, flh antibody, notochord homeobox antibody, notochord homeobox S homeolog antibody, NOTO antibody, not.S antibody, Noto antibody, not antibody, noto antibody

Background: Noto is a transcription regulator acting downstream of both FOXA2 and T during notochord development.Noto is required for node morphogenesis.Noto is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning, acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate.
Alias Symbols: Flh, MmNot, Not, tc
Protein Size: 240

Molecular Weight: 26 kDa

Gene ID: 384452

NCBI Accession: NM_001007472, NP_001007473

UniProt: A8MTQ0