NCOA3 antibody (Middle Region)

Catalog No. ABIN2779677

Product Details anti-NCOA3 Antibody

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOA3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: DQNPVESSMC QSNSRDHLSD KESKESSVEG AENQRGPLES KGHKKLLQLL

Predicted Reactivity: Cow: 77%, Dog: 90%, Horse: 92%, Human: 100%, Mouse: 83%, Pig: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against NCOA3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NCOA3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1420 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NCOA3

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Alternative Name: NCOA3 (NCOA3 Products)

Synonyms: NCOA3 antibody, ACTR antibody, AIB-1 antibody, AIB1 antibody, CAGH16 antibody, CTG26 antibody, KAT13B antibody, RAC3 antibody, SRC-3 antibody, SRC3 antibody, TNRC14 antibody, TNRC16 antibody, TRAM-1 antibody, bHLHe42 antibody, pCIP antibody, 2010305B15Rik antibody, AW321064 antibody, Actr antibody, Aib1 antibody, Rac3 antibody, Src3 antibody, Tram-1 antibody, Tram1 antibody, p/Cip antibody, pCip antibody, actr antibody, aib-1 antibody, aib1 antibody, cagh16 antibody, ctg26 antibody, kat13b antibody, pcip antibody, rac3 antibody, src-3 antibody, src3 antibody, tnrc14 antibody, tnrc16 antibody, tram-1 antibody, xSRC-3 antibody, nuclear receptor coactivator 3 antibody, nuclear receptor coactivator 3 S homeolog antibody, NCOA3 antibody, Ncoa3 antibody, ncoa3.S antibody

Background: NCOA3 is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.
Alias Symbols: ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, MGC141848, RAC3, SRC-1, SRC3, TNRC14, TNRC16, TRAM-1, pCIP, SRC-3, bHLHe42
Protein Interaction Partner: PSMB9, PPARG, CUL3, ARNT2, MMS19, FBXW7, SPOP, UBC, E2F1, PTEN, ESR2, ALB, NR1I2, THRB, CHUK, KANK2, ESR1, NR3C1, MYOCD, MKL1, MKL2, PSME3, UBE3A, TP53, RARA, MAPK1, PIN1, PGR, EP300, ELAVL1, MAPK14, CREBBP, CEBPD, CEBPA, TP53BP1, TFF1, PSMC5, PSMA3, PRKC
Protein Size: 1420

Molecular Weight: 155 kDa

Gene ID: 8202

NCBI Accession: NM_006534, NP_006525

UniProt: Q0VF45

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha