SIRT4 antibody (N-Term)
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- Target See all SIRT4 Antibodies
- SIRT4 (Sirtuin 4 (SIRT4))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Cow, Dog, Pig, Horse, Rabbit, Sheep, Guinea Pig, Goat, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SIRT4 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- ASPPLDPEKV KELQRFITLS KRLLVMTGAG ISTESGIPDY RSEKVGLYAR
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
- Characteristics
- This is a rabbit polyclonal antibody against SIRT4. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human SIRT4
- Top Product
- Discover our top product SIRT4 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 314 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SIRT4 (Sirtuin 4 (SIRT4))
- Alternative Name
- SIRT4 (SIRT4 Products)
- Synonyms
- SIRT4 antibody, im:7139453 antibody, SIR2L4 antibody, 4930596O17Rik antibody, sirtuin 4 antibody, SIRT4 antibody, sirt4 antibody, Sirt4 antibody
- Background
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SIRT4 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT4 is included in class IV of the sirtuin family. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Alias Symbols: MGC130046, MGC130047, MGC57437, SIR2L4, sirtuin 4
Protein Interaction Partner: SKP2, Glud1, UBC, SIRT3, IDE, SLC25A6, SLC25A5,
Protein Size: 314 - Molecular Weight
- 35 kDa
- Gene ID
- 23409
- NCBI Accession
- NM_012240, NP_036372
- UniProt
- Q9Y6E7
- Pathways
- Negative Regulation of Hormone Secretion
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