OTX2 antibody (N-Term)

Catalog No. ABIN2779643

Product Details anti-OTX2 Antibody

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Zebrafish (Danio rerio), Dog, Sheep, Rabbit, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OTX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: PESRVQVWFK NRRAKCRQQQ QQQQNGGQNK VRPAKKKTSP AREVSSESGT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against OTX2. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human OTX2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 297 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-OTX2 antibody (ABIN2779643)

Machali?ska, Kawa, Pius-Sadowska, Rogi?ska, K?os, Baumert, Wiszniewska, Machali?ski: "Endogenous regeneration of damaged retinal pigment epithelium following low dose sodium iodate administration: an insight into the role of glial cells in retinal repair." in: Experimental eye research, Vol. 112, pp. 68-78, (2013) (PubMed).

Aluigi, Angelini, Corte, Falugi: "The sea urchin, Paracentrotus lividus, embryo as a "bioethical" model for neurodevelopmental toxicity testing: effects of diazinon on the intracellular distribution of OTX2-like proteins." in: Cell biology and toxicology, Vol. 24, Issue 6, pp. 587-601, (2008) (PubMed).

Takeda, Yokoyama, Yasumoto, Saito, Udono, Takahashi, Shibahara: "OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium." in: Biochemical and biophysical research communications, Vol. 300, Issue 4, pp. 908-14, (2003) (PubMed).

Target Details for OTX2

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Alternative Name: OTX2 (OTX2 Products)

Synonyms: CPHD6 antibody, MCOPS5 antibody, E130306E05Rik antibody, id:ibd2915 antibody, zOtx2 antibody, zgc:136535 antibody, zotx-2 antibody, Xotx-2 antibody, Xotx2 antibody, otx-2 antibody, otx2 antibody, orthodenticle homeobox 2 antibody, orthodenticle homeobox 2 S homeolog antibody, orthodenticle homeobox 2 L homeolog antibody, OTX2 antibody, Otx2 antibody, otx2 antibody, otx2.S antibody, otx2.L antibody

Background: Homeobox protein OTX2 is a member of the bicoid sub-family of homeodomain-containing transcription factors. This protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined. This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.
Alias Symbols: MCOPS5, MGC45000, CPHD6
Protein Interaction Partner: ATXN1, CDK4, APP, DMBX1, TLE4, FOXA2, MITF, OTX2, LHX1,
Protein Size: 297

Molecular Weight: 32 kDa

Gene ID: 5015

NCBI Accession: NM_021728, NP_068374

Pathways: Dopaminergic Neurogenesis