SIRT1 antibody (N-Term)
-
- Target See all SIRT1 Antibodies
- SIRT1 (Sirtuin 1 (SIRT1))
-
Binding Specificity
- N-Term
-
Reactivity
- Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This SIRT1 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Sequence
- PETIPPPELD DMTLWQIVIN ILSEPPKRKK RKDINTIEDA VKLLQECKKI
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
- Characteristics
- This is a rabbit polyclonal antibody against SIRT1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human SIRT1
- Top Product
- Discover our top product SIRT1 Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 747 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
-
Localization of sirtuins (SIRT1-7) in the aged mouse inner ear." in: Acta oto-laryngologica, pp. 1-12, (2015) (PubMed).
: "Butyric acid-induced rat jugular blood cytosolic oxidative stress is associated with SIRT1 decrease." in: Cell stress & chaperones, Vol. 19, Issue 2, pp. 295-8, (2014) (PubMed).
: "Changes in energy-regulated molecules in the trophocytes and fat cells of young and old worker honeybees (Apis mellifera)." in: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 69, Issue 8, pp. 955-64, (2014) (PubMed).
: "Energy-regulated molecules maintain young status in the trophocytes and fat cells of old queen honeybees." in: Biogerontology, Vol. 15, Issue 4, pp. 389-400, (2014) (PubMed).
: "Risk assessment in patients with depressed left ventricular function after myocardial infarction using the myocardial performance index--Survival and Ventricular Enlargement (SAVE) experience." in: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Vol. 19, Issue 1, pp. 28-33, (2006) (PubMed).
: "
-
Localization of sirtuins (SIRT1-7) in the aged mouse inner ear." in: Acta oto-laryngologica, pp. 1-12, (2015) (PubMed).
-
- Target
- SIRT1 (Sirtuin 1 (SIRT1))
- Alternative Name
- SIRT1 (SIRT1 Products)
- Synonyms
- sirtuin 1 antibody, AA673258 antibody, SIR2L1 antibody, Sir2 antibody, Sir2a antibody, Sir2alpha antibody, sir2l1 antibody, sirtuin antibody, SIR2 antibody, sirtuin 1 antibody, sirtuin 1 L homeolog antibody, SIRT1 antibody, SRT1 antibody, Sirt1 antibody, sirt1.L antibody
- Background
-
SIRT1 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined,
Alias Symbols: SIR2L1
Protein Interaction Partner: SIRT2, KAT5, IRS1, ING2, ING1, HSP90AA1, AR, EP300, CDK1, CCNB1, RPS19BP1, KAT8, CLOCK, IRS2, UBE2I, TP53, STK11, WRN, PPARGC1A, FOXO1, VHL, UBC, E2F1, PSME3, KCNA5, KCNA4, KCNAB2, POP1, PPARA, CAP1, KIAA1598, TPM4, FASN, CDKL1, HIC1, HDAC4, CHD3, CDK6, S
Protein Size: 747 - Molecular Weight
- 82 kDa
- Gene ID
- 23411
- NCBI Accession
- NM_012238, NP_036370
- UniProt
- Q96EB6
- Pathways
- MAPK Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Negative Regulation of intrinsic apoptotic Signaling
-