SIX Homeobox 1 antibody (Middle Region)

Catalog No. ABIN2779599

Product Details anti-SIX Homeobox 1 Antibody

Target: SIX Homeobox 1 (SIX1)

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Cow, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIX Homeobox 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: SEEEFSPPQS PDQNSVLLLQ GNMGHARSSN YSLPGLTASQ PSHGLQTHQH

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against SIX1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SIX1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 284 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SIX Homeobox 1 antibody (ABIN2779599)

Lee, Kim, Ryu, Lee, Yang, Jeong, Kim, Lee, Kim, Hajjar, Park: "Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy." in: Journal of molecular and cellular cardiology, Vol. 52, Issue 3, pp. 718-26, (2012) (PubMed).

Target Details for SIX Homeobox 1

Target: SIX Homeobox 1 (SIX1)

Alternative Name: SIX1 (SIX1 Products)

Synonyms: BOS3 antibody, DFNA23 antibody, TIP39 antibody, BB138287 antibody, six1b antibody, six2 antibody, zgc:92332 antibody, XSix1 antibody, six1 antibody, zgc:77345 antibody, SIX homeobox 1 antibody, sine oculis-related homeobox 1 antibody, SIX homeobox 1a antibody, SIX homeobox 1 L homeolog antibody, SIX homeobox 1b antibody, SIX1 antibody, Six1 antibody, six1a antibody, six1.L antibody, six1b antibody

Background: SIX1 is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BOS3, DFNA23, TIP39
Protein Interaction Partner: AES, VTN, FZR1, UBC, SKI, CCDC85B, DACH1, EYA3, EYA2, MDFI, EYA4, EYA1, SIX1, TLE1,
Protein Size: 284

Molecular Weight: 32 kDa

Gene ID: 6495

NCBI Accession: NM_005982, NP_005973

UniProt: Q15475

Pathways: Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development