SCMH1 antibody (Middle Region)

Catalog No. ABIN2779551

Product Details anti-SCMH1 Antibody

Target: SCMH1 (Sex Comb On Midleg Homolog 1 (SCMH1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Saccharomyces cerevisiae, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCMH1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KTAEPLKFPK KRGPKPGSKR KPRTLLNPPP ASPTTSTPEP DTSTVPQDAA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 91%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against SCMH1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SCMH1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 591 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SCMH1

Target: SCMH1 (Sex Comb On Midleg Homolog 1 (SCMH1))

Alternative Name: SCMH1 (SCMH1 Products)

Synonyms: Scml3 antibody, AI315320 antibody, AI851618 antibody, Scml1 antibody, zgc:162582 antibody, Scm polycomb group protein homolog 1 antibody, sex comb on midleg homolog 1 (Drosophila) antibody, sex comb on midleg homolog 1 antibody, Scm polycomb group protein homolog 1 L homeolog antibody, SCMH1 antibody, Scmh1 antibody, scmh1 antibody, scmh1.L antibody

Background: SCMH1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Alias Symbols: Scml3
Protein Interaction Partner: UBQLN1, RNF2, MAGEA12, BMI1, UBQLN4, PHC3, CBX4, PCGF2, PHC2, PHC1, MAML3, LZTR1, PCBD1, EWSR1, TMEM11, SCMH1, MOB4, TOB1, POLR2M, LYPLA2, GMNN, HK1, Cbx2,
Protein Size: 591

Molecular Weight: 65 kDa

Gene ID: 22955

NCBI Accession: NM_012236, NP_036368