IRX2 antibody (Middle Region)

Catalog No. ABIN2779496

Product Details anti-IRX2 Antibody

Target: IRX2 (Iroquois Homeobox Protein 2 (IRX2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Horse, Guinea Pig, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRX2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LEDDEDDDEE GERGLAPPKP VTSSPLTGLE APLLSPPPEA APRGGRKTPQ

Predicted Reactivity: Cow: 79%, Dog: 93%, Guinea Pig: 91%, Horse: 93%, Human: 100%, Mouse: 92%, Rat: 83%

Characteristics: This is a rabbit polyclonal antibody against IRX2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IRX2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 471 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-IRX2 antibody (ABIN2779496)

Kadota, Sato, Duncan, Ooshima, Yang, Diaz-Meyer, Gere, Kageyama, Fukuoka, Nagata, Tsukada, Dunn, Wakefield, Lee: "Identification of novel gene amplifications in breast cancer and coexistence of gene amplification with an activating mutation of PIK3CA." in: Cancer research, Vol. 69, Issue 18, pp. 7357-65, (2009) (PubMed).

Target Details for IRX2

Target: IRX2 (Iroquois Homeobox Protein 2 (IRX2))

Alternative Name: IRX2 (IRX2 Products)

Synonyms: IRXA2 antibody, Irx5 antibody, IRX6 antibody, iroquois homeobox 2 antibody, Iroquois related homeobox 2 (Drosophila) antibody, IRX2 antibody, Irx2 antibody

Background: IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.
Alias Symbols: IRXA2
Protein Interaction Partner: MAPK3,
Protein Size: 471

Molecular Weight: 49 kDa

Gene ID: 153572

NCBI Accession: NM_033267, NP_150366

UniProt: Q9BZI1

Pathways: Tube Formation