ERCC8 antibody (N-Term)
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- Target See all ERCC8 Antibodies
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Dog, Rabbit, Cow, Pig, Guinea Pig, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ERCC8 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- DVERIHGGGI NTLDIEPVEG RYMLSGGSDG VIVLYDLENS SRQSYYTCKA
- Predicted Reactivity
- Cow: 77%, Dog: 85%, Guinea Pig: 77%, Human: 100%, Mouse: 85%, Pig: 85%, Rabbit: 85%, Rat: 77%, Zebrafish: 85%
- Characteristics
- This is a rabbit polyclonal antibody against ERCC8. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human ERCC8
- Top Product
- Discover our top product ERCC8 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 396 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
- Alternative Name
- ERCC8 (ERCC8 Products)
- Synonyms
- zgc:103550 antibody, CKN1 antibody, CSA antibody, UVSS2 antibody, Ckn1 antibody, 2410022P04Rik antibody, 2810431L23Rik antibody, 4631412O06Rik antibody, B130065P18Rik antibody, Csa antibody, excision repair cross-complementation group 8 antibody, ERCC excision repair 8, CSA ubiquitin ligase complex subunit antibody, excision repaiross-complementing rodent repair deficiency, complementation group 8 antibody, ercc8 antibody, ERCC8 antibody, Ercc8 antibody
- Background
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ERCC8 is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
Alias Symbols: CKN1, CSA
Protein Interaction Partner: CUL4A, CUL4B, DDB1, RUVBL2, ZNF24, PCNA, H1F0, ERCC6, UVSSA, DDA1, RFWD2, COPS4, COPS6, COPS3, TOP1, TP53, SSBP1, OGG1, MDM2, GTF2H2, CUL5, GPS1, DDB2, COPS2, COPS7A, COPS5, COPS8, RBX1, POLR2A, HMGN1, EP300, UBC, CSNK2B, XAB2, UQCRQ, CBR1,
Protein Size: 396 - Molecular Weight
- 44 kDa
- Gene ID
- 1161
- NCBI Accession
- NM_000082, NP_000073
- UniProt
- Q13216
- Pathways
- DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
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