MTF1 antibody (C-Term)
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- Target See all MTF1 Antibodies
- MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))
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Binding Specificity
- C-Term
- Reactivity
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MTF1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- QSSLVMGEQN LQWILNGATS SPQNQEQIQQ ASKVEKVFFT TAVPVASSPG
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against MTF1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human MTF1
- Top Product
- Discover our top product MTF1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 753 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))
- Alternative Name
- MTF1 (MTF1 Products)
- Synonyms
- MTF-1 antibody, MTF1 antibody, mtf1 antibody, MGC86485 antibody, Thyls antibody, ZRF antibody, metal regulatory transcription factor 1 antibody, metal-regulatory transcription factor 1 antibody, metal-regulatory transcription factor 1 L homeolog antibody, metal response element binding transcription factor 1 antibody, MTF1 antibody, mtf1 antibody, mtf1.L antibody, Mtf1 antibody
- Background
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The zinc finger transcription factor MTF-1 (metal-responsive transcription factor-1) is conserved from insects to vertebrates. The major role of MTF-1 in both organisms is to control the transcription of genes involved in the homeostasis and detoxification of heavy metal ions such as Cu2+, Zn2+ and Cd2+. In mammals, MTF-1 serves at least two additional roles. First, targeted disruption of the MTF-1 gene results in death at embryonic day 14 due to liver degeneration, revealing a stage-specific developmental role. Second, under hypoxic-anoxic stress, MTF-1 helps to activate the transcription of the gene placental growth factor (PIGF), an angiogenic protein.
Alias Symbols: ZRF, MTF-1
Protein Interaction Partner: AP1M1, EP300, CREBBP, MT1G,
Protein Size: 753 - Molecular Weight
- 81 kDa
- Gene ID
- 4520
- NCBI Accession
- NM_005955, NP_005946
- UniProt
- Q14872
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