CLK4 antibody (N-Term)

Catalog No. ABIN2779361

Product Details anti-CLK4 Antibody

Target: CLK4 (CDC-Like Kinase 4 (CLK4))

Binding Specificity: N-Term

Reactivity: Mouse, Human, Rabbit, Dog, Guinea Pig, Cow, Horse, Rat, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLK4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RSRRSSPKRK RNRHCSSHQS RSKSHRRKRS RSIEDDEEGH LICQSGDVLR

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 93%, Yeast: 91%

Characteristics: This is a rabbit polyclonal antibody against CLK4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CLK4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 481 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CLK4 antibody (ABIN2779361)

Eisenreich, Zakrzewicz, Huber, Thierbach, Pepke, Goldin-Lang, Schultheiss, Pries, Rauch: "Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells." in: Oncology reports, Vol. 30, Issue 1, pp. 462-70, (2013) (PubMed).

Target Details for CLK4

Target: CLK4 (CDC-Like Kinase 4 (CLK4))

Alternative Name: CLK4 (CLK4 Products)

Synonyms: AI987988 antibody, C85119 antibody, zgc:112975 antibody, CDC like kinase 4 antibody, CDC-like kinase 4 antibody, CDC-like kinase 4b antibody, CLK4 antibody, Clk4 antibody, clk4b antibody

Background: The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined.
Alias Symbols: DKFZp686A20267
Protein Interaction Partner: KPNA1, KRTAP10-3, KRTAP10-8, KRTAP10-9, KRTAP10-7, CLK4, SRRM2, AHCYL2, SUB1, RASA4, SRPK1, RNF181, CLASRP, UBL5, HSPB2,
Protein Size: 481

Molecular Weight: 57 kDa

Gene ID: 57396

NCBI Accession: NM_020666, NP_065717

UniProt: Q9HAZ1