FASL antibody (Middle Region)

Catalog No. ABIN2779355

Product Details anti-FASL Antibody

Target: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Binding Specificity: Middle Region

Reactivity: Human, Pig, Cow, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FASL antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MHTASSLEKQ IGHPSPPPEK KELRKVAHLT GKSNSRSMPL EWEDTYGIVL

Predicted Reactivity: Cow: 86%, Horse: 79%, Human: 100%, Pig: 93%, Rabbit: 90%

Characteristics: This is a rabbit polyclonal antibody against FASLG. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 281 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FASL

Target: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Alternative Name: FASLG (FASL Products)

Background: TNFSF6 is a cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T cell mediated apoptosis and in T cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
Alias Symbols: APT1LG1, CD178, CD95L, FASL, TNFSF6, CD95-L
Protein Interaction Partner: RGS20, TRIP6, NOTCH2NL, KRT40, FAS, CFLAR, FADD, CASP8, NCF1, MACC1, SH3PXD2B, SNX33, SH3RF2, RIMBP3C, SNX18, EPS8L3, ARHGAP9, SAMSN1, MPP4, SRGAP1, BAIAP2L1, NCKIPSD, SNX9, MYO15A, ITSN2, TJP3, OSTF1, SRGAP2, DNMBP, SORBS3, SRGAP3, DOCK4, SH3PXD2A, KALRN
Protein Size: 281

Molecular Weight: 31 kDa

Gene ID: 356

NCBI Accession: NM_000639, NP_000630

UniProt: P48023

Pathways: Apoptosis, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity