TYK2 antibody (C-Term)
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- Target See all TYK2 Antibodies
- TYK2 (Tyrosine Kinase 2 (TYK2))
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Binding Specificity
- C-Term
- Reactivity
- Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TYK2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- HRDLAARNVL LDNDRLVKIG DFGLAKAVPE GHEYYRVRED GDSPVFWYAP
- Predicted Reactivity
- Cow: 91%, Dog: 100%, Guinea Pig: 91%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against TYK2. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human TYK2
- Top Product
- Discover our top product TYK2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 1187 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- TYK2 (Tyrosine Kinase 2 (TYK2))
- Alternative Name
- TYK2 (TYK2 Products)
- Synonyms
- JTK1 antibody, tyrosine kinase 2 antibody, TYK2 antibody, Tyk2 antibody
- Background
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This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Alias Symbols: JTK1
Protein Interaction Partner: KHDRBS2, KRT40, TRAF4, HNRNPK, FHL3, COPS5, JAK3, UBC, HSP90AA1, TYK2, PTAFR, EIF2AK2, LNX1, KLF10, SOCS1, TK1, DNM2, IFNAR1, JAKMIP1, XRCC5, STAM2, PRMT5, IFNAR2, CRKL, GHR, IRS2, IL6ST, STAT2, STAT1, IL13RA1, GNB2L1, PTPN1, PTPN6, PDGFRB, PLAUR, PIK3R1,
Protein Size: 1187 - Molecular Weight
- 134 kDa
- Gene ID
- 7297
- NCBI Accession
- NM_003331, NP_003322
- UniProt
- P29597
- Pathways
- JAK-STAT Signaling, Hepatitis C
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