Amphiregulin antibody (Middle Region)

Catalog No. ABIN2779308

Product Details anti-Amphiregulin Antibody

Target: Amphiregulin (AREG)

Binding Specificity: Middle Region

Reactivity: Human, Cow, Dog, Horse, Pig, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Amphiregulin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PQIPGYIVDD SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR

Predicted Reactivity: Cow: 91%, Dog: 91%, Horse: 91%, Human: 100%, Pig: 91%, Sheep: 91%

Characteristics: This is a rabbit polyclonal antibody against AREG. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human AREG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 252 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Amphiregulin

Target: Amphiregulin (AREG)

Alternative Name: AREG (AREG Products)

Background: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.
Alias Symbols: AR, AREGB, CRDGF, MGC13647, SDGF
Protein Interaction Partner: KRTAP10-3, WDR92, UBC, APP, UBQLN4, WT1, EGFR, CCND3, MMP9,
Protein Size: 252

Molecular Weight: 28 kDa

Gene ID: 374

NCBI Accession: NM_001657, NP_001648

UniProt: P15514

Pathways: RTK Signaling, EGFR Signaling Pathway