XRN1 antibody (Middle Region)

Catalog No. ABIN2779146

Product Details anti-XRN1 Antibody

Target: XRN1 (5'-3' Exoribonuclease 1 (XRN1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Pig, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XRN1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LPQEISQVNQ HHKSGFNDNS VKYQQRKHDP HRKFKEECKS PKAECWSQKM

Predicted Reactivity: Cow: 92%, Dog: 93%, Guinea Pig: 79%, Horse: 90%, Human: 100%, Mouse: 86%, Pig: 85%, Rabbit: 100%, Rat: 100%, Yeast: 90%

Characteristics: This is a rabbit polyclonal antibody against XRN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human XRN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1706 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for XRN1

Target: XRN1 (5'-3' Exoribonuclease 1 (XRN1))

Alternative Name: XRN1 (XRN1 Products)

Synonyms: wu:fk92c07 antibody, zgc:63635 antibody, SEP1 antibody, Dhm2 antibody, exo antibody, mXrn1 antibody, RGD1309713 antibody, 5'-3' exoribonuclease 1 antibody, xrn1 antibody, XRN1 antibody, Tsp_05930 antibody, Xrn1 antibody

Background: SEP1 (XRN1) localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-67 BX640905.1 1-67 68-5188 AY137776.1 1-5121 5189-5269 BG197321.1 308-388 5270-10092 AC023508.16 31718-36540 c
Alias Symbols: DKFZp434P0721, DKFZp686B22225, DKFZp686F19113, FLJ41903, SEP1
Protein Interaction Partner: ZFP36, UBC, RPA3, RPA2, RPA1, BMI1, HECW2, HERC2P4, RNF187, B3GALT6, EXOSC6, C1orf85, VWA5B2, MFSD5, PRADC1, ANGPTL6, PLEKHG2, SPATA20, C1GALT1, DCP1A, HEATR1, NDUFA13, EXOSC1, DPP7, RBMX, MTCH2, TMEM50A, CD97, ATP5G2, SNHG1, LINC01541, DCP1B, SRRM2, SKIV
Protein Size: 1706

Molecular Weight: 194 kDa

Gene ID: 54464

NCBI Accession: NM_019001, NP_061874

UniProt: Q8IZH2