RG9MTD1 antibody (Middle Region)

Catalog No. ABIN2779118

Product Details anti-RG9MTD1 Antibody

Target: RG9MTD1 (RNA (Guanine-9-) Methyltransferase Domain Containing 1 (RG9MTD1))

Binding Specificity: Middle Region

Reactivity: Human, Rabbit, Mouse, Rat, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RG9MTD1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MKRKELQNTV SQLLESEGWN RRNVDPFHIY FCNLKIDGAL HRELVKRYQE

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against RG9MTD1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RG9MTD1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 403 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-RG9MTD1 antibody (ABIN2779118)

Szczepanowska, Maiti, Kukat, Hofsetz, Nolte, Senft, Becker, Ruzzenente, Hornig-Do, Wibom, Wiesner, Krüger, Trifunovic: "CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels." in: The EMBO journal, Vol. 35, Issue 23, pp. 2566-2583, (2016) (PubMed).

Target Details for RG9MTD1

Target: RG9MTD1 (RNA (Guanine-9-) Methyltransferase Domain Containing 1 (RG9MTD1))

Alternative Name: RG9MTD1 (RG9MTD1 Products)

Background: RG9MTD1 functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends.
Alias Symbols: FLJ20432, MRPP1, RG9MTD1
Protein Interaction Partner: CEP76, CEP57, TP53, SUMO2, SUMO3, GRSF1, UBC, ASB1, UBD, CAND1, CUL3, HDGF, USP39,
Protein Size: 403

Molecular Weight: 47 kDa

Gene ID: 54931

NCBI Accession: NM_017819, NP_060289

UniProt: Q7L0Y3