RENT2/UPF2 antibody (N-Term)
-
- Target See all RENT2/UPF2 (UPF2) Antibodies
- RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))
-
Binding Specificity
- N-Term
- Reactivity
- Human, Rat, Mouse, Horse, Pig, Cow, Saccharomyces cerevisiae, Zebrafish (Danio rerio), Dog
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This RENT2/UPF2 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Sequence
- KAPEDKKKRL EDDKRKKEDK ERKKKDEEKV KAEEESKKKE EEEKKKHQEE
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rat: 86%, Yeast: 86%, Zebrafish: 86%
- Characteristics
- This is a rabbit polyclonal antibody against UPF2. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human UPF2
- Top Product
- Discover our top product UPF2 Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 1272 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))
- Alternative Name
- UPF2 (UPF2 Products)
- Synonyms
- HUPF2 antibody, RENT2 antibody, smg-3 antibody, UPF2, regulator of nonsense mediated mRNA decay antibody, UPF2 regulator of nonsense transcripts homolog (yeast) antibody, UPF2 antibody, Upf2 antibody, upf2 antibody
- Background
-
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene, both variants encode the same protein.
Alias Symbols: DKFZp434D222, HUPF2, KIAA1408, MGC138834, MGC138835, RENT2, smg-3
Protein Interaction Partner: PUF60, UBC, UPF1, LGR4, MIF, LDHA, KRT18, ITGB1, HMGA1, ZBTB48, HBZ, ENO1, E4F1, CYBA, CALR, BLM, ATP1B3, ART4, DCP1B, DCP2, COMTD1, EXOSC6, GADD45GIP1, ZGPAT, MAP1LC3B, ZNF408, CENPU, WNK1, RSRC2, MRPL40, ZNF44, EXOSC1, MTERF3, GLTSCR2, NOB1, RRP7A, SERB
Protein Size: 1272 - Molecular Weight
- 148 kDa
- Gene ID
- 26019
- NCBI Accession
- NM_015542, NP_056357
- UniProt
- Q9HAU5
-