PUM2 antibody (N-Term)

Catalog No. ABIN2779082

Product Details anti-PUM2 Antibody

Target: PUM2 (Pumilio Homolog 2 (Drosophila) (PUM2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Pig, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PUM2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SSPADKLDSR FRKGNFGTRD AETDGPEKGD QKGKASPFEE DQNRDLKQGD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PUM2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PUM2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1064 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PUM2 antibody (ABIN2779082)

Hynes, Calder, Rosenfeld, Scott: "The use of tranexamic acid to reduce blood loss during total hip arthroplasty: an observational study." in: Annals of the Royal College of Surgeons of England, Vol. 87, Issue 2, pp. 99-101, (2005) (PubMed).

Target Details for PUM2

Target: PUM2 (Pumilio Homolog 2 (Drosophila) (PUM2))

Alternative Name: PUM2 (PUM2 Products)

Synonyms: pum-2 antibody, 5730503J23Rik antibody, Pumm2 antibody, mKIAA0235 antibody, PUMH2 antibody, PUML2 antibody, pumilio RNA binding family member 2 antibody, pumilio RNA-binding family member 2 antibody, pum2 antibody, Pum2 antibody, PUM2 antibody

Background: PUM2 is a sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
Alias Symbols: KIAA0235, PUMH2, PUML2
Protein Interaction Partner: NANOS3, BMI1, gag-pol, UBC, DAZL, DAZ1, ELAVL1, MED4, AURKA, NANOS1, DAZ2, DAZ4, PUM2, MED23, IKZF5,
Protein Size: 1064

Molecular Weight: 117 kDa

Gene ID: 23369

NCBI Accession: NM_015317, NP_056132

Pathways: Ribonucleoprotein Complex Subunit Organization